EvolGenius Population Genetics Software for Windows and Mac/Unix
EvolGenius v6.1 follows the fate of
alleles at two genes in a population of constant size. Users can
set the linkage map distance between the two genes, as well as the
mutation rates for each gene. Users can also set the relative
fitnesses for all nine possible genotypes, and they can set relative
mating preferences based on genotype. The program also allows
for immigration from a population with pre-determined genotype
frequencies. In addition to tracking allele frequencies, the
program can also determine when every gene copy descends from a
single ancestral copy -- i.e., it allows for consideration
of drift/coalescence and effective population size. Final haplotype
and genotype frequencies are reported.
EvolGenius allows the user to
perform a large number of iterations of the simulation using the
same program settings. A single output file (.csv formart) can then be imported
into a spreadsheet program for further statistical analysis. A separate .txt file reports program
settings and summary data.
Changes from previous versions. The source code has been modified to compile and run correctly in both Windows
and MacOS; the previous version only ran in Windows. The option to allow for assortative mating is now available. The main
output file is now a .csv file, with empty cells filled with "NA" to allow easy import into R and Microsoft Excel.
Note: bug fix (Feb 15, 2016) Due to a limitation of floating point resolution, the sum of
genotype proportions in immigrants could be erroneously flagged as exceeding 1.0. This is now fixed.
Validation. The program has been extensively tested in Windows 7 and MacOS 10.7, and produces output that
is consistent with predictions from population genetics theory (see validation report below). That said, I cannot
guarantee that it is free from errors. The c++ source code is available for download; my only request is that proper
attribution be made if the code is re-compiled or modified.
An overview of the inner workings of EvolGenius can be found on
Scitable, the Nature Publshing Group's online educational
to read the article, which also provides advice on using the program. The program manual (below) covers similar
Pre-compiled executable for Windows (zipped file)
Pre-compiled executable for Mac/Unix (zipped file)
C++ source code (code)
Software guide (manual)
Quick guide (guide)
Validation report (validation)